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apalutamide will lessen the level or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicines which can be CYP3A4 substrates may lead to lower exposure to those medications.Akutt og alvorlig allergisk reaksjon med sy